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PAGANZ virtual meeting 2022 : registration is open! David Foster (Sun 23:57:47 EDT).2022 Pharmacometrics Summer Internship at Boehringer Ingelheim US nikolas.onufrak (Mon 08:21:09 EDT).
FSHER MATRIX NONMEM PSP
FSHER MATRIX NONMEM SOFTWARE
We implemented this expression as a generic function for two software applications: S-PLUS and MATLAB. This involved the development of an expression for the Fisher information matrix for nonlinear mixed-effects models, including estimation of the variance of the residual error. In this paper we propose simple programming tools to evaluate population pharmacokinetic designs. Methods based on the Fisher information matrix have been developed and extended to population studies to evaluate and optimize designs. In population pharmacokinetic studies, the precision of parameter estimates is dependent on the population design.